Fresh analysis suggests that patients who discontinue popular slimming jabs like Wegovy and Mounjaro can put back on lost weight far faster than those who stop traditional lifestyle plans.
Findings released in a major medical journal demonstrates that while obese individuals often shed a large proportion of their body weight while using the jabs, the mass is regained at an average rate of nearly a kilo each month after stopping.
"Individuals purchasing these drugs should be aware of the danger of rapid rebound weight gain when the therapy ends," warns researcher Dr. Susan Jebb.
Such speed of recovery suggests a reversion to starting weight within about a year and a half.
Comparing Therapies
The research, which examined 37 of trials involving over 9,000 of participants, compared the outcomes of GLP-1 agonists with other pills.
The team note that individuals who shed pounds through diet and exercise usually experience a less rapid weight regain—perhaps 0.1 kg a month—once they finish.
Understanding the Fast Regain
Nutrition scientists suggest the mode of action of the jabs is key to understanding the accelerated regain.
GLP-1 drugs mimic a natural hormone called GLP-1, which controls hunger.
"Long-term administration of GLP-1 concentrations far above than the body's typical production might result in the system to generate a reduced amount of its own natural GLP-1, and could diminish sensitivity to its effects," said Dr. Adam Collins, a nutrition researcher.
"Discontinuation of this hormone supplement results in hunger is unsuppressed, making binge eating far more likely."
A Chronic Disease?
Health authorities recommend the jabs for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Professionals contend that, given the likelihood of relapse, the therapy should be considered life-long.
This view is echoed by drug manufacturers, who state that the results "underscore the persistent character of excess weight," similar to managing diseases like hypertension.
Patient Experiences
People who have come off the jabs describe a powerful resurgence of appetite.
"I experienced a trigger activating and I was suddenly ravenous," described one woman.
The struggle is exacerbated if patients have not developed sustainable dietary or behavioural modifications during therapy.
Growing Interest
Survey data suggest that millions of people in the UK have used weight-loss jabs in the last 12 months, with desire being substantial.
- Use is more common among females than men.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, researchers stress that while these medications are effective agents for shedding pounds, they are not a magic fix and lasting health benefits likely depends on combined behavioural management.
